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Updated: Jun 28, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
Uncoupling protein 1: a short-circuit in the chemiosmotic process
1School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. rkporter@tcd.ie
Abstract:
One of the significant naturally occurring short-circuits in the chemiosmotic process is manifest through the activity of uncoupling protein 1, most notably present in the inner membrane of mitochondria in brown adipose tissue. Much has been learnt about the mechanism of action of uncoupling protein 1 since its discovery in the 1970's, yet many areas of controversy surround (i) the mechanism of its action, (ii) novel regulators of its activity, and (iii) the tissue specificity of its expression. In this mini-review, areas of controversy are highlighted from the aforementioned categories using selected key experiments to demonstrate the arguments.
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