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Immunotoxicity testing in non-rodent species

Helen G Haggerty1

  • 1Bristol-Myers Squibb, Syracuse, New York 13221, USA. helen.haggerty@bms.com

Journal of Immunotoxicology
|October 30, 2008
PubMed

Evaluation of the immunotoxicity potential of some pharmaceuticals, including immunomodulatory chemicals and biologics, cannot be limited to testing in rodents. Thus, immune function tests have also been applied in studies with non-human primates and more recently dogs that assess various components of the immune system. These assays include TDAR responses with various immunogens, lymphocyte phenotyping, natural-killer cell activity, delayed-type hypersensitivity, and macrophage function assays. Approaches for incorporating immune function testing in non-rodent species, results from these tests, their interpretation and limitations with respect to drug safety assessment will be reviewed.

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