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Updated: Jun 28, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Thyroid function after hysterosalpingography using an oil-soluble iodinated contrast medium.

Keiko Mekaru¹, Shigeru Kamiyama, Hitoshi Masamoto

¹Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology

|October 30, 2008

Summary

Hysterosalpingography (HSG) with lipiodol may affect thyroid function, potentially causing hypothyroidism, especially in women with pre-existing subclinical hypothyroidism. Monitoring thyroid function post-HSG is crucial for early detection and management.

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Area of Science:

Endocrinology
Radiology
Infertility Management

Background:

Hysterosalpingography (HSG) is a common procedure for infertility evaluation.
Lipiodol, an oil-soluble iodinated contrast medium, is frequently used in HSG.
The impact of lipiodol on thyroid function requires further investigation.

Purpose of the Study:

To assess the effect of lipiodol-enhanced HSG on thyroid function in infertile women.
To identify potential risks and patient subgroups susceptible to thyroid dysfunction after HSG.

Main Methods:

Serum free thyroxine (FT4) and thyrotropin-stimulating hormone (TSH) levels were measured before and after HSG in 214 infertile women.
Patients were categorized based on pre-HSG thyroid function: euthyroid, subclinical hypothyroidism, and subclinical hyperthyroidism.
Thyroid function was monitored for several months following the procedure.

Main Results:

A significant increase in hypothyroidism development was observed in the subclinical hypothyroidism group post-HSG compared to euthyroid patients.
Three patients in the subclinical hypothyroidism group required thyroid hormone replacement therapy.
No significant changes were noted in the subclinical hyperthyroidism group.

Conclusions:

Thyroid function monitoring is recommended after HSG using lipiodol, particularly for patients with subclinical hypothyroidism.
Pre-HSG TSH and FT4 measurements are essential to identify at-risk individuals.
Early detection and management can prevent the progression of hypothyroidism.