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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Crocidolite and mesothelioma.

Frank Schneider¹, Thomas A Sporn, Victor L Roggli

¹Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA. frank.schneider@duke.edu

Ultrastructural Pathology

|October 30, 2008

Summary

This summary is machine-generated.

Crocidolite asbestos, a potent mesothelioma-causing fiber, is increasingly detected in U.S. patients. Its presence rose significantly between 1982 and 2005, while other asbestos types declined.

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Published on: October 2, 2015

Area of Science:

Environmental Health
Occupational Medicine
Pathology

Background:

Asbestos exposure is a known cause of malignant mesothelioma.
Different asbestos fiber types have varying potencies in disease pathogenesis.
Historical data on asbestos fiber detection in mesothelioma patients is crucial for understanding exposure trends.

Purpose of the Study:

To analyze temporal changes in asbestos fiber type detection in U.S. mesothelioma patients.
To investigate the increasing detection of crocidolite (blue asbestos) in relation to mesothelioma.
To assess the significance of crocidolite detection, particularly in the absence of other asbestos types.

Main Methods:

Retrospective analysis of asbestos fiber types detected in lung tissue samples from mesothelioma patients.
Comparison of fiber detection frequencies between 1982 and 2005.
Detailed examination of cases with isolated crocidolite detection.

Main Results:

The frequency of crocidolite detection in U.S. mesothelioma patients increased from 19% to 37% between 1982 and 2005.
The percentage of crocidolite fibers in detected lung tissue rose from 4% to 10% during the study period.
Simultaneously, the detection frequency of amosite and chrysotile asbestos decreased.
A notable increase in cases with crocidolite detected alone was observed in recent years.

Conclusions:

Crocidolite is becoming more prevalent in U.S. mesothelioma cases, suggesting a shift in exposure patterns.
The rising incidence of crocidolite, the most potent asbestos fiber, is a significant concern for mesothelioma pathogenesis.
Further research into current asbestos exposure sources is warranted to address this trend.