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Updated: Jun 28, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

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Published on: January 17, 2018

[Pregnancy in active acromegaly].

R Sahli1, E Christ

  • 1Poliklinik für Endokrinologie, Diabetologie und klinische Ernährung Inselspital-Universitätsspital Bern, Schweiz. Rahel.Sahli@insel.ch

Deutsche Medizinische Wochenschrift (1946)
|October 30, 2008
PubMed
Summary
This summary is machine-generated.

Pregnancy with acromegaly is rare but possible. This case shows a successful pregnancy despite active acromegaly, with improved maternal vision and infant health.

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Last Updated: Jun 28, 2026

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Neurosurgery

Background:

  • Acromegaly, a condition caused by excess growth hormone, often leads to menstrual irregularities and infertility.
  • Pituitary macroadenomas can cause visual disturbances and hormonal imbalances.

Observation:

  • A 29-year-old woman with oligoamenorrhea and acromegaly became pregnant.
  • Diagnosis was confirmed by elevated IGF-1 and pituitary macroadenoma on MRI.
  • She underwent transsphenoidal surgery during pregnancy, with subsequent visual and biochemical improvements.

Findings:

  • The patient delivered a healthy infant after an uncomplicated pregnancy.
  • Postpartum assessment revealed persistent acromegaly activity, necessitating further treatment.
  • Biochemical improvement during pregnancy, though rare, was observed in this case.

Implications:

  • Pregnancy in active acromegaly increases maternal risks like hypertension and gestational diabetes.
  • While tumor growth is a concern, pregnancy can paradoxically lead to biochemical improvement.
  • This case highlights the possibility of successful pregnancy and delivery in acromegaly patients.