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Mumps outbreaks in vaccinated populations: are available mumps vaccines effective enough to prevent outbreaks?

Gustavo H Dayan1, Steven Rubin

  • 1Clinical Department, Sanofi Pasteur, Swiftwater, Pennsylvania, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 31, 2008
PubMed

Insights

Mumps outbreaks in vaccinated people highlight vaccine performance issues. Current mumps vaccines, especially with one dose or the Rubini strain, show variable effectiveness, necessitating improved vaccines or policies.

Area of Science:

  • Epidemiology
  • Vaccinology
  • Public Health

Background:

  • Mumps outbreaks are increasingly reported in populations with high vaccination coverage.
  • This trend necessitates a critical evaluation of existing mumps vaccine performance.

Purpose of the Study:

  • To review the effectiveness of different mumps vaccine strains and doses.
  • To identify factors contributing to mumps outbreaks in vaccinated individuals.

Main Methods:

  • Systematic review of studies reporting mumps vaccine effectiveness (VE).
  • Analysis of VE data based on vaccine strain (Jeryl Lynn, Urabe, Rubini) and number of doses.
  • Examination of outbreak data in relation to vaccination coverage and vaccine strain.

Main Results:

  • Single-dose vaccine effectiveness varied: Jeryl Lynn (72.8%–91%), Urabe (54.4%–93%), Rubini (0%–33%).
  • Two-dose vaccine effectiveness ranged from 91% to 94.6%.
  • Waning immunity and antigenic differences between vaccine and outbreak strains were identified as contributing factors.

Conclusions:

  • The Rubini vaccine strain and inadequate vaccine coverage are linked to most outbreaks.
  • Some outbreaks occurred despite high coverage with two doses of the Jeryl Lynn vaccine.
  • There is a need for more effective mumps vaccines and/or revised vaccination strategies.

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