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Updated: Jun 28, 2026

Measurement of Extracellular Ion Fluxes Using the Ion-selective Self-referencing Microelectrode Technique
Published on: May 3, 2015
Glass electrode measurements of sodium in albumin solutions
1Department of Radiation Biology and Biophysics University of Rochester School of Medicine and Dentistry Rochester, New York 14620, U.S.A.
Abstract:
Measurements of the sodium level of albumin solutions and their ultrafiltrates were made with commercially available sodium-sensitive glass electrodes. The potential of the electrode was found to vary considerably with the depth of immersion. The potentials of albumin solutions which were allowed to remain at room temperature or higher for any length of time were found to increase, and in time gave unrealistic levels of sodium activity. An albumin solution stored in a refrigerator for a month did not show this effect. The sodium levels of albumin solutions as determined by the electrode were lower than the flame photometric values for the same solutions.
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