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Updated: Jun 28, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Light-scattering, X-ray diffraction, elemental analysis and infrared spectro- photometry characterization of
R A Muzzareli1, A Ferrero, M Pizzoli
1G. Ciamician" Chemical Institute University of Bologna Via Selmi 2, Bologna 40126, Italy.
Abstract:
Measurements on chitosan, which is used as a selective chromatographic support in inorganic chromatography, show that its molecular weight is 1.2 x 10(5), the nitrogen content is 7.4%, and its crystalline structure is not lost after adsorption of metal ions, which are co-ordinated with the nitrogen atoms of the -NH(2) groups of the polymer. Chitosan treated with copper sulphate exhibits a new crystal structure and a distinctive infrared spectrum, is quite stable and does not shrink, and is proposed as a chromatographic support for ligand-exchange chromatography.

