Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Preparation and Reactions of Thiols

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.

Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate

Alkenes can be dihydroxylated using potassium permanganate. The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.

Oxidation of Alcohols

Oxidation of Alcohols

In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:

Redox Titration: Other Oxidizing and Reducing Agents

Redox Titration: Other Oxidizing and Reducing Agents

Besides iodine, other oxidizing or reducing agents can serve as titrants in redox titrations. Common oxidizing titrants include KMnO4, cerium(IV), and K2Cr2O7. The choice of oxidizing titrants depends on factors like stability, cost, analyte strength, and reaction rate between the analyte and titrant. KMnO4 is a strong oxidizing titrant that reduces from Mn(VII) to Mn(II) in a highly acidic solution, simultaneously oxidizing the analyte to a higher oxidation state. In this case, KMnO4 acts as a...

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.

Journal of medicinal chemistry·1996

Same author

Deprivation and cause specific morbidity: evidence from the Somerset and Avon survey of health.

BMJ (Clinical research ed.)·1996

Same author

The influence of merocyanine 540 and protoporphyrin on physicochemical properties of the erythrocyte membrane.

Biochimica et biophysica acta·1996

Same author

Accelerated fetal lung maturity profiles and maternal cocaine exposure.

Obstetrics and gynecology·1996

Same author

ABT-431: the diacetyl prodrug of A-86929, a potent and selective dopamine D1 receptor agonist: in vitro characterization and effects in animal models of Parkinson's disease.

The Journal of pharmacology and experimental therapeutics·1996

Same author

Psychopathological syndromes in the functional psychoses: associations with course and outcome.

Psychological medicine·1996

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

Vanadium(V) as an oxidant for thiol compounds.

R S Ramakrishna¹, M Williams

¹Department of Chemistry, University of Ceylon, Colombo Campus Ceylon, Sri lanka.

|October 1, 1977

Summary

This summary is machine-generated.

Vanadium(V) oxidizes thiols to disulfides. Selenium(IV) in hydrochloric acid also oxidizes thiosalicylic acid solely to its disulfide, not mixed products.

More Related Videos

Chemical Vapor Deposition of an Organic Magnet, Vanadium Tetracyanoethylene

Chemical Vapor Deposition of an Organic Magnet, Vanadium Tetracyanoethylene

Published on: July 3, 2015

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

Published on: May 23, 2018

Related Experiment Videos

Last Updated: Jun 28, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

Chemical Vapor Deposition of an Organic Magnet, Vanadium Tetracyanoethylene

Chemical Vapor Deposition of an Organic Magnet, Vanadium Tetracyanoethylene

Published on: July 3, 2015

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

Published on: May 23, 2018

Area of Science:

Analytical Chemistry
Inorganic Chemistry

Background:

Thiol oxidation is crucial in biological and chemical processes.
Understanding metal ion redox chemistry informs analytical method development.

Purpose of the Study:

To investigate the oxidation of thiol compounds by Vanadium(V).
To develop a photometric method for Vanadium(V) estimation.
To clarify the reaction mechanism of Selenium(IV) with thiosalicylic acid.

Main Methods:

Oxidation reactions of thiols with Vanadium(V).
Spectrophotometric analysis for vanadium determination.
Reinvestigation of Selenium(IV)-thiosalicylic acid reaction in concentrated HCl.

Main Results:

Vanadium(V) effectively oxidizes various thiols to disulfides.
A reliable photometric procedure for quantifying Vanadium(V) in complex matrices was established.
Selenium(IV) exclusively yields disulfides from thiosalicylic acid, without forming mixed diselenides.

Conclusions:

Vanadium(V) serves as a potent oxidant for thiols.
The developed photometric method allows for accurate Vanadium(V) quantification.
Selenium(IV) acts as a clean oxidant, producing only disulfides in this reaction.