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Related Experiment Video

Updated: Jun 28, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

J L Burgot1

  • 1Laboratoire de Chimie Minérale B, Groupe de Cristallographie et Chimie du Solide, L.A. 251, Universite de Caen, 14032 Caen, France.

Talanta
|June 1, 1978
PubMed
Summary
This summary is machine-generated.

This study demonstrates thermometric titration for analyzing phenothiazine derivatives. The method provides sharp titration curves for accurate quantification of these important pharmaceutical compounds.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry
  • Medicinal Chemistry

Context:

  • Phenothiazine derivatives are crucial in pharmaceuticals.
  • Accurate quantification of these compounds is essential for quality control.
  • Traditional titration methods may face challenges with solubility and reaction enthalpies.

Purpose:

  • To develop and validate a thermometric titration method for phenothiazine derivatives.
  • To analyze the impact of pK(a), solubility, and enthalpy of neutralization on titration accuracy.
  • To establish a reliable analytical technique for promethazine hydrochloride and related compounds.

Summary:

  • Acids conjugated to phenothiazine derivatives were titrated with sodium hydroxide using an automatic thermometric titrimeter.

Related Experiment Videos

Last Updated: Jun 28, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

  • The study observed sharp, analytically useful breaks in titration curves.
  • Key parameters influencing titration accuracy, including pK(a), product solubility, and enthalpy of neutralization, were investigated for promethazine hydrochloride.

    • Impact:

    • Provides a robust analytical method for phenothiazine derivative quantification.
    • Enhances understanding of factors affecting thermometric titrations.
    • Facilitates quality control and drug development for phenothiazine-based medications.