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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis and properties of a new chelating resin containing the oxime group
A Sugii1, N Ogawa, H Hashizume
1Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862, Japan.
Abstract:
A macroreticular polystyrene-based chelating resin with oxime and diethylamino functional groups has been synthesized. The resin is stable in acid and alkaline solutions; no decrease in nitrogen content or capacity for sorption of copper(II) is observed when it is exposed to 3M hydrochloric acid and 1M sodium hydroxide for 7 days. The resin has higher selectivity for copper(II) than for other metal ions tested and the time required for 50% uptake of copper(II) is 15 min. The highest capacity for copper(II) is 2.0 mmole/g at pH 6.0. In a column operation, quantitative recovery of copper(II) is achieved by elution with 1M hydrochloric acid, and the resin can be used repeatedly.
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