Related Experiment Video
Updated: Jun 28, 2026

Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
Published on: February 20, 2020
Coulometric titration of anilines, mainly containing deactivating functional groups, with bromine
1Department of Technical Analytical Chemistry, Chemical Center, Lund, Sweden.
Abstract:
A general method is described for the coulometric titration of various substituted anilines with anodically generated bromine. The reaction is carried out in water-acetic acid medium and the reactivity is governed by varying the water content and the bromide concentration, and by the addition of pyridine. In this way the majority of the substituted anilines tested can be titrated quantitatively. There is no great difference in the reactivity-promoting properties of pyridine-free and pyridine-containing media, but the latter generally give the better results and are therefore to be preferred. The mean relative error, for the best medium for each compound, is +/-0.5% for the haloanilines and +/-1.0% for anilines with oxygenated functional groups.
More Related Videos
Related Concept Videos
Titration in Nonaqueous Solvents
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Classification of Titrimetric Analysis Based on Reaction Types
Titrations between an acid and a base lead to neutralization reactions that form...
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Titrimetric Methods: Types and Commonly Used Strategies

