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Polarographic determination of ampicillin in capsules and tablets
J A Squella1, L J Nunez-Vergara
1Department of Chemical Pharmacology and Physical Chemistry, Faculty of Chemical and Pharmacological Sciences, University of Chile, Santiago, Chile.
Abstract:
A new polarographic method is used for quantitative analysis of ampicillin dosage forms. The electroactive product is formed by acidic hydrolysis of ampicillin. It gives a well-developed reduction wave with half-wave potential of -0.91 V vs. SCE. The proposed method has good precision. A major advantage is the selectivity, which makes the determination of ampicillin possible without prior separation of the excipient.
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