Related Experiment Video
Updated: Jun 28, 2026
Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
Effectiveness and safety of loop electrosurgical excision procedure for cervical neoplasia in rural India
Rengaswamy Sankaranarayanan1, Vijay Keshkar, Ashok Kothari
1Screening Group, International Agency for Research on Cancer, Lyon, France. sankar@iarc.fr
Objective:
To evaluate the effectiveness and safety of loop electrosurgical excision procedure (LEEP) to treat cervical intraepithelial neoplasia (CIN) in rural India.
Method:
Women with CIN colposcopic features unsuitable for cryotherapy were treated with LEEP using a "see-and-treat" approach. Women with unsatisfactory colposcopy had diagnostic LEEP. Cure was defined as no clinical or histologic evidence of CIN at 1-year follow-up. Factors influencing cure rates were evaluated by chi(2) tests.
Results:
Of the 1,141 women who underwent LEEP (569 see-and-treat; 572 unsatisfactory colposcopy), 634 had histologically proven CIN. Of those, 489 reported for follow-up and 459 (93.9%) had no evidence of disease. Cure rates were 98.1% for women with CIN 1, 93.6% for CIN 2, and 85.0% for CIN 3. Patients with CIN 2-3 had significantly lower cure rates.
Conclusion:
Cure rates for LEEP provided by newly trained doctors in rural India were similar to those reported in the gynecological literature.
