Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental changes in tracheal structure.

K S Deoras1, M R Wolfson, R L Searls

  • 1Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

Pediatric Research
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxygen saturation and work of breathing indices in preterm infants with bronchopulmonary dysplasia compared to healthy preterm infants at discharge.

Journal of neonatal-perinatal medicine·2024
Same author

The impact of kangaroo mother care on work of breathing and oxygen saturation in very low birth weight infants with respiratory insufficiency.

Journal of neonatal-perinatal medicine·2022
Same author

A novel in-line high frequency interrupter for use with bubble CPAP: A feasibility study in a premature lamb model.

Journal of neonatal-perinatal medicine·2022
Same author

Effects of xenon gas on human airway epithelial cells during hyperoxia and hypothermia.

Journal of neonatal-perinatal medicine·2020
Same author

Pulmonary mechanics measurements by respiratory inductive plethysmography and esophageal manometry: Methodology for infants on non-invasive respiratory support.

Journal of neonatal-perinatal medicine·2019
Same author

High flow nasal heliox improves work of breathing and attenuates lung injury in a newborn porcine lung injury model.

Journal of neonatal-perinatal medicine·2016
Same journal

Prenatal cannabinoid and nicotine exposure: senescence as a developmental origin of bronchopulmonary dysplasia?

Pediatric research·2026
Same journal

Bob Sun: ECI Biocommentary.

Pediatric research·2026
Same journal

The involvement of Anaeroplasma, caproic acid, and interleukins through the brain-gut axis may contribute to IgAV with neurological involvement.

Pediatric research·2026
Same journal

Emerging role of microplastics and nanoplastics in children's health.

Pediatric research·2026
Same journal

Serum cytokine profiling reveals distinct inflammatory signatures in Kawasaki disease and MIS-C and suggests associations with coronary artery lesions.

Pediatric research·2026
Same journal

Protective effects of dexpanthenol on experimental colitis in young rats: modulation of p53/BAX/BCL2 and RIPK1/RIPK3/MLKL signaling with anti-inflammatory activity.

Pediatric research·2026
See all related articles

Airway stiffness increases with age due to changes in tracheal structure. This study examined tracheal development in lambs, finding that growth and maturation alter airway architecture, leading to increased stiffness in older animals.

Area of Science:

  • Respiratory physiology
  • Developmental biology
  • Biomechanical engineering

Background:

  • Airway mechanical properties change significantly during development, transitioning from compliant to stiffer airways with age.
  • While adult airway structure-function relationships are understood, developmental changes remain largely unexplored.

Purpose of the Study:

  • To investigate the hypothesis that changes in tracheal morphometry correlate with developmental shifts in tracheal function.
  • To elucidate the architectural alterations underlying the increasing stiffness of proximal airways during early development.

Main Methods:

  • Anatomic, morphometric, and histochemical analyses were performed on tracheal segments from 29 lambs.
  • Lambs' ages ranged from 70% gestation to 6 days post-birth.

Related Experiment Videos

Main Results:

  • Tracheal dimensions and tracheal wall component sizes increased with maturation.
  • The geometric arrangement of the tracheal rings underwent alterations.
  • Cartilage composition within the trachea changed as the lambs matured.

Conclusions:

  • Developmental changes in tracheal architecture, including dimensions, ring geometry, and cartilage composition, contribute to increased airway stiffness in older animals.
  • These architectural modifications explain observed functional differences in the trachea during early development.