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Published on: February 5, 2015
Apoptosis-related molecules in blood in multiple sclerosis
Sanna Rinta1, Hanna Kuusisto, Minna Raunio
1Neuroimmunology Unit, Department of Neurology, Finn-Medi 3, Biokatu 10, 33014 University of Tampere, Finland.
Abstract:
A failure in apoptosis of lymphocytes may lead to harmful immunoreactivity in MS. We analyzed apoptosis-related molecules including TRAIL, sFas, sFasL and MIF in the blood of 117 MS patients and controls to answer whether these molecules may be used in the evaluation of disease activity and immunomodulatory effect of IFN-beta. Increased levels of sTRAIL, sFasL and MIF were found in sera of untreated patients with MS relapse indicating their association with MS disease activity. IFN-beta treated patients in remission had increased TRAIL mRNA, sTRAIL, sFaL and MIF that most likely reflect bioactivity of IFN-beta.
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