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o-Iodosobenzoate as an oxidimetric titrant
Talanta
|September 1, 1982
Summary
This study details analytical methods using o-iodosobenzoate and bromine for quantifying various sulfur compounds, pharmaceuticals, and antioxidants. These titrations offer precise determination of diverse analytes in chemical and biological samples.
Area of Science:
- Analytical Chemistry
- Quantitative Analysis
- Titrimetry
Background:
- Accurate quantification of sulfur-containing compounds and pharmaceuticals is crucial in various scientific disciplines.
- Development of robust analytical methods is essential for quality control and research.
Purpose of the Study:
- To present versatile titration methods utilizing o-iodosobenzoate and bromine.
- To establish procedures for the determination of specific analytes, including sulfur compounds, pharmaceuticals, and antioxidants.
Main Methods:
- Titration with o-iodosobenzoate under different pH conditions (neutral and acidic).
- Titration with bromine, including methods for masking interfering substances and pre-treatment of analytes.
- Utilizing specific indicators and reagents like potassium iodide, starch, Methyl Red, cysteine, and acrylonitrile.
Main Results:
- Established methods for determining tetrathionate, hydrogen sulphite, thiosulphate, xanthates, cysteine, and glutathione.
- Successful determination of Hexacyanoferrate(II) in the presence of interfering ions.
- Quantified bromine consumption by various sulfonamides (sulphathiazole, sulphadiazine, sulphamerazine), chloramphenicol, rutin, and vitamin C.
Conclusions:
- o-Iodosobenzoate and bromine serve as effective titrants for a wide range of analytes.
- The described methods provide reliable quantification for complex mixtures and diverse chemical species.
- The study contributes valuable analytical protocols for chemical and pharmaceutical analysis.
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