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Published on: November 15, 2013
[Not Available].
1Laboratoire de Chimie Analytique, Faculté de Pharmacie de Monastir, Tunisie.
Talanta
|August 1, 1984
Summary
This study explores the electrochemical oxidation of therapeutic flavonols, establishing a link between their structure and behavior. This method enables simultaneous identification, determination, and purity assessment of pharmaceuticals.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Medicinal Chemistry
Context:
- Flavonols are compounds with therapeutic potential, particularly for vascular health.
- Understanding their electrochemical properties is crucial for developing analytical methods.
- The study focuses on flavonols derived from o-diphenol quercetol.
Purpose:
- To investigate the electrochemical oxidation of therapeutic flavonols using d.c. and pulse polarography.
- To establish a relationship between the structure of these flavonols and their electrochemical behavior.
- To propose an application for electrochemical methods in pharmaceutical drug analysis.
Summary:
- Electrochemical oxidation of several therapeutic flavonols derived from o-diphenol quercetol was studied using rotating solid electrode voltammetry.
- The influence of solvent and pH on the electrochemical response was examined.
- A structure-electrochemical behavior relationship was established, enabling simultaneous identification, determination, and purity assay of pharmaceuticals within a linear range of 5 x 10(-6)-10(-4)M.
Impact:
- Provides a novel electrochemical approach for the simultaneous analysis of pharmaceuticals.
- Facilitates accurate identification, quantification, and purity assessment of drug compounds.
- Offers a sensitive and reliable method for quality control in the pharmaceutical industry.
