Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics: Overview01:10

Pharmacokinetics: Overview

9.7K
Pharmacokinetics is a scientific discipline that focuses on the journey of a drug within the body, encompassing four key stages: absorption, distribution, metabolism, and elimination. The first stage, absorption, involves the drug's transfer into the bloodstream. Several factors dictate the extent and speed of this process. For example, the liver often metabolizes oral drugs before they reach systemic circulation, leading to only partial absorption. In contrast, intravenous (IV)...
9.7K
Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs01:21

Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

3.4K
The fundamental mathematical principles, such as calculus and graphs, play crucial roles in analyzing drug movement and determining pharmacokinetic parameters. Differential calculus examines rates of change and helps to determine the dissolution rate of drugs in biofluids, as well as how drug concentrations change over time. For instance, it can help calculate the rate of elimination of a drug from the body based on its concentration-time profile.
On the other hand, integral calculus focuses on...
3.4K
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

727
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
727
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

426
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
426
Measurement of Bioavailability: Pharmacokinetic Methods01:30

Measurement of Bioavailability: Pharmacokinetic Methods

517
Pharmacokinetics is a vital branch of pharmacology that examines how drugs are absorbed, distributed, metabolized, and excreted by the body. Two key methodologies in pharmacokinetics are plasma drug concentration studies and urinary drug excretion analyses, both of which provide critical insights into a drug's therapeutic efficacy and bioavailability.Plasma Drug Concentration-Time StudiesPlasma drug concentration-time studies involve analyzing blood samples at specific intervals to quantify...
517
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

1.0K
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

INTRAMUSCULAR 15(S)15 METHYL PGF<sub>2α</sub> IN THE TREATMENT OF MISSED ABORTION.

Acta obstetricia et gynecologica Scandinavica·2017
Same author

Endobronchial valves in the management of broncho-pleural and alveolo-pleural fistulae.

Lung·2012
Same author

A multicenter pilot study of a bronchial valve for the treatment of severe emphysema.

Respiration; international review of thoracic diseases·2009
Same author

Vaso-active therapy can improve 6-min walk distance in patients with pulmonary hypertension and fibrotic interstitial lung disease.

Respiratory medicine·2008
Same author

Hepatopulmonary syndrome following portopulmonary hypertension.

The European respiratory journal·2007
Same author

From cystic pulmonary airway malformation, to bronchioloalveolar carcinoma and adenocarcinoma of the lung.

The European respiratory journal·2005
Same journal

Detection and cross-organ characterization of physiological response to microplastic stress in Panax ginseng based on hyperspectral imaging assisted with machine learning.

Talanta·2026
Same journal

Electron-driven proton transfer behaviors in oxidative DNA lesion 8-oxoguanine: A computational study.

Talanta·2026
Same journal

TiO<sub>2</sub> nanoengineering for high-performance photoelectrochemical biosensors: From fundamental strategies to frontier applications.

Talanta·2026
Same journal

CRISPR-based diagnostics for ESKAPE drug-resistant bacteria: From proof-of-concept to point-of-care.

Talanta·2026
Same journal

Integrated 3D printed wearable microfluidics with removable electrochemical sensor for morphine monitoring in sweat.

Talanta·2026
Same journal

Eu-doped Tourmaline@MOF-ZnO core-shell nanocomposites: Enabling UV-activated room-temperature and ppb-level n-butanol sensing.

Talanta·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K

Pharmacokinetics and the analytical chemist.

A C Mehta1

  • 1Department of Pharmacy, The General Infirmary, Leeds, Yorkshire, England.

Talanta
|March 1, 1987
PubMed
Summary
This summary is machine-generated.

Analytical method development for drug and metabolite assays requires understanding basic pharmacokinetic principles. This knowledge aids in interpreting results and collaborating with medical specialists.

More Related Videos

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
09:50

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Published on: April 28, 2019

9.0K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.3K

Related Experiment Videos

Last Updated: May 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K
Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
09:50

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Published on: April 28, 2019

9.0K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.3K

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Biomedical Science

Background:

  • Accurate quantification of parent drugs and metabolites in biological fluids is crucial for pharmacokinetic studies.
  • Method development and application necessitate familiarity with pharmacokinetic principles and terminology.
  • Understanding pharmacokinetics enhances assay result interpretation and interdisciplinary collaboration.

Purpose of the Study:

  • To introduce fundamental concepts of pharmacokinetics.
  • To discuss biological processes relevant to pharmacokinetic studies.
  • To highlight areas of pharmacokinetics pertinent to analytical chemists.

Main Methods:

  • Review of pharmacokinetic principles.
  • Discussion of relevant biological processes.
  • Focus on analytical chemistry applications.

Main Results:

  • Provides a foundational understanding of pharmacokinetics for analytical chemists.
  • Explains key biological processes influencing drug disposition.
  • Identifies essential pharmacokinetic concepts for assay development.

Conclusions:

  • Familiarity with pharmacokinetics is essential for analytical chemists developing drug assay methods.
  • Understanding pharmacokinetic principles improves the interpretation of analytical data.
  • This review serves as a guide for analytical chemists entering pharmacokinetic studies.