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Spectrophotometric determination of clofibrate
1Pharmacy Department, Faculty of Technology and Engineering, M.S. University of Baroda, Kalabhavan, Baroda 390 001, India.
Talanta
|March 1, 1987
Abstract:
A sensitive method for the rapid and accurate determination of clofibrate by hydroxamic acid formation is described. Hydroxylamine hydrochloride is reacted with clofibrate in alkaline medium to give 4-chlorophenoxyisobutyrohydroxamic acid, which forms a purple complex with iron(III) in acidic medium. Common excipients do not interfere.
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