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Introduction to Solid Supported Membrane Based Electrophysiology

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A trimethoprim-selective membrane electrode.

S Z Yao¹, J Shiao, L H Nie

¹New Material Research Institute, Department of Chemical Engineering, Hunan University, Changsha People's Republic of China.

|December 1, 1987

Summary

This summary is machine-generated.

A new sensor selectively detects trimethoprim (TMP) using an ion-pair complex. This trimethoprim sensor offers rapid, interference-free potentiometric determination, aiding in drug analysis.

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Area of Science:

Analytical Chemistry
Electrochemistry
Pharmaceutical Analysis

Background:

Trimethoprim (TMP) is an important antibiotic.
Accurate and rapid determination of TMP is crucial for therapeutic drug monitoring and quality control.
Existing analytical methods may lack specificity or speed.

Purpose of the Study:

To develop a novel ion-selective electrode (ISE) for the rapid and selective determination of trimethoprim.
To investigate the performance characteristics of the developed TMP-ISE.
To evaluate the potential of the ISE for practical applications in potentiometric analysis.

Main Methods:

Construction of an ion-selective electrode based on the ion-pair complex of trimethoprim with silicotungstate.
Potentiometric measurements to determine the electrode's response to varying trimethoprim concentrations.
Testing for interferences from common sulpha-drugs.

Main Results:

The developed electrode exhibited a rapid response to trimethoprim concentration changes.
The electrode showed good selectivity, with no significant interference from sulpha-drugs.
The response slope was measured at 51.0 +/- 1.5 mV/decade over the concentration range of 3 x 10(-5) to 2 x 10(-2) M.

Conclusions:

A novel and selective electrode for trimethoprim determination has been successfully developed.
The trimethoprim-silicotungstate complex provides an effective basis for potentiometric sensing.
The electrode is suitable for the rapid and reliable potentiometric determination of trimethoprim in relevant samples.