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Adsorptive stripping voltammetry for the determination of nifedipine in human serum
R J Diez-Caballero1, L L de la Torre, J F Valentin
1Department of Analytical Chemistry, Colegio Universitario de Alava, Aptdo. 450, Vitoria, Spain.
Abstract:
Adsorptive stripping voltammetry is used for the determination of trace levels of nifedipine. The conditions for preconcentration on the mercury drop electrode have been studied and the final measurements are made by differential pulse voltammetry. The response is linear from 2 x 10(-9) to 1 x 10(-7)M and can be extended to 10(-6)M by a change in conditions. The stripping peak has been used for determination of the drug in formulations, with a relative standard deviation of 0.8%. The method is applicable to the determination of nifedipine in blood-serum with a detection limit of 4.1 ng/ml.
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