Related Experiment Video
Updated: Jun 28, 2026

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
Published on: March 1, 2018
Studies on the polarographic behaviour of estazolam
1Department of Chemistry, Beijing Normal University, Beijing , 100875, People's Republic of China.
Abstract:
In 0.1M NH(3)-NH(4)Cl buffer (pH 9.2) a sensitive 2-electron reduction wave of estazolam is obtained by single-sweep oscillopolarography. The peak potential is -1.08 V (vs. SCE). The peak height is proportional to the concentration of estazolam over the range 1.0 x 10(-7)-9.0 x 10( partial differential)M. The detection limit is 5.0 x 10(-8)M. The behaviour of the reduction wave has been studied and applied to the determination of estazolam. The reduction process is irreversible and the wave shows adsorptive characteristics, the behaviour obeying the Frumkin adsorption isotherm. The adsorption coefficient beta is 1.16 x 10(6) 1./mole and the interaction factor alpha is -1.06. The mechanism of the electrode reaction is discussed.
Related Concept Videos
Voltammetric Techniques: Linear-Scan (E vs Time)
Voltammetry: Stripping Methods
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...
Measuring Reaction Rates
Electrogravimetric Analysis: Overview
To test the completeness of the...
Voltammetric Techniques: Pulse Voltammetry
E2 Reaction: Stereochemistry and Regiochemistry
When a substrate with two different β hydrogens undergoes an E2 elimination, the presence of a strong base can yield two regioisomeric alkenes. The more-substituted alkene is the major product and...

