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Published on: August 22, 2017
Micro-determination of warfarin sodium, nicoumalone and acebutolol hydrochloride in pharmaceutical preparations
C S Sastry1, T T Rao, A Sailaja
1Foods and Drugs Laboratories, School of Chemistry, Andhra University, Visakhapatnam 530 003, India.
Abstract:
A simple, selective and sensitive spectrophotometric method has been developed for the determination of microgram quantities of warfarin sodium (WS), nicoumalone (NIC) and acebutolol hydrochloride (ACBH), either in pure form or in pharmaceutical preparations. This method is based on the haloform reaction with a known and excess of standard iodine solution under alkaline conditions. The excess of iodine is determined at pH 3.0 with metol-INH. The absorbance of the resulting p-N-methyl-benzoquinonemonoimine-INH charge-transfer complex is measured at 620 nm.
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