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Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

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Chloroquine polymeric membrane electrodes: Development and applications.

B Saad¹, K Kanapathy, M N Ahmad

¹School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.

|December 1, 1991

Summary

This summary is machine-generated.

New PVC solvent polymeric membrane ion-selective electrodes for chloroquine analysis were developed. The best electrode, using tetraphenylborate (TPB) and trioctyl phosphate (TOP), offers a low detection limit for accurate tablet assays.

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Area of Science:

Electrochemistry
Analytical Chemistry
Materials Science

Background:

Ion-selective electrodes (ISEs) are crucial for potentiometric analysis.
PVC-based membranes offer versatility in ISE development.
Accurate determination of chloroquine is important for pharmaceutical quality control.

Purpose of the Study:

To develop and characterize novel PVC solvent polymeric membrane ion-selective electrodes for chloroquine.
To evaluate the performance of electrodes based on different ion-pairing agents and solvent mediators.
To assess the suitability of the optimized electrode for the quantitative analysis of chloroquine in pharmaceutical formulations.

Main Methods:

Fabrication of PVC-based membranes incorporating ion-pairing agents: dipicrylamine (DPA), tetraphenylborate (TPB), or tetrakis(4-chlorophenyl)borate (TCPB).
Use of solvent mediators: dioctylphenyl phosphonate (DOPP) or trioctyl phosphate (TOP).
Potentiometric measurements to evaluate Nernstian response, dynamic response time, pH range, and limit of detection.

Main Results:

All developed electrodes demonstrated Nernstian responses, rapid dynamic response times, and a broad useful pH range.
The electrode utilizing tetraphenylborate (TPB) and trioctyl phosphate (TOP) exhibited the best overall performance, with a limit of detection of 7.1 x 10(-6)M.
The optimized TPB-TOP electrode successfully quantified chloroquine in tablets using direct potentiometry, yielding results comparable to the official method.

Conclusions:

PVC solvent polymeric membrane ion-selective electrodes offer a viable and sensitive method for chloroquine determination.
The TPB- and TOP-based electrode provides a reliable analytical tool for chloroquine assay in pharmaceutical samples.
This approach presents an effective alternative to conventional methods for chloroquine analysis.