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Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

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Published on: September 7, 2011

Flow-injection coulometric titrations.

R H Taylor¹, J Růzicka, G D Christian

¹Center for Process Analytical Chemistry, Department of Chemistry, BG-10, University of Washington, Seattle, WA 98195, U.S.A.

|March 1, 1992

Summary

This summary is machine-generated.

This study introduces a novel flow-injection analysis system using stop-flow coulometric titrations for automated sample analysis. The technique offers high precision for titrating sodium hydroxide and nitric acid across wide concentration ranges.

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Area of Science:

Analytical Chemistry
Electrochemistry

Background:

Conventional coulometric titrations face challenges with reagent handling, storage, and degradation.
Automated analytical methods are crucial for improving efficiency and accuracy in chemical analysis.

Purpose of the Study:

To develop and validate a flow-injection analysis (FIA) technique based on stop-flow coulometric titrations.
To integrate key components into a single unit for streamlined analysis.
To assess the system's performance for titrating strong acids and bases.

Main Methods:

A novel flow-injection analysis system was designed, incorporating a gradient chamber, reagent generation chamber, and detector flow cell.
Stop-flow functionality enabled automated sample dilution up to 100-fold.
Remote spectrophotometric detection was achieved using optical fibers.
The system eliminated the need for frits or membranes between electrodes.

Main Results:

The system successfully titrated sodium hydroxide (5 x 10(-4)-4M) and nitric acid (5 x 10(-3)-15M).
Analyses achieved a relative standard deviation of less than 3% across the entire concentration range.
A correlation coefficient of 0.999 was obtained when compared to manual titrations.

Conclusions:

The developed stop-flow coulometric titration system provides an accurate and precise method for analyzing strong acids and bases.
It retains the advantages of conventional coulometric titration while overcoming reagent handling issues.
The integrated design and automated dilution enhance analytical workflow efficiency.