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Updated: Jun 28, 2026
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
Published on: July 10, 2016
Reliable and facile method for preparation of solventless bilayer lipid membranes for electroanalytical
1Chemical Sensors Group, Department of Chemistry, Erindale Campus, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario, Canada LSL 1C6.
Abstract:
Bilayer lipid membranes continue to be of interest as elements for development and investigation of chemically-modified electrodes and biosensors, yet also continue to be difficult to prepare and replicate with precision. A simplified and reliable technique for the rapid formation of solventless bilayer lipid membranes is described, and the method has been shown to produce membranes which nominally vary by only 5-10% with respect to ion conductivity. Methods for rapid physical and chemical characterization of these membranes for establishment of reproducibility and quality are given.
