Bromometric determination of carbimazole

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis

Background:

• Carbimazole is an important antithyroid drug.
• Accurate quantification of carbimazole is crucial for pharmaceutical quality control.

Purpose of the Study:

• To develop and validate direct and indirect bromometric titration methods for carbimazole analysis.
• To assess the applicability of these methods for carbimazole in tablet formulations.

Main Methods:

• Direct bromometric titration using N-bromosuccinimide (NBS) with methyl red indicator.
• Indirect titrations employing NBS, potassium bromate, and dibromohydantoin (DBH).
• Thin-layer chromatography (TLC), infrared (IR), and nuclear magnetic resonance (NMR) spectroscopy for product analysis.

Main Results:

• Direct titration is accurate for 2-12 mg carbimazole (100.2 ± 0.5% accuracy).
• Indirect titrations show high accuracy for various drug quantities (1-16 mg).
• Methods were successfully applied to tablet analysis, validated by standard addition.

Conclusions:

• Developed bromometric titration methods offer reliable and accurate quantification of carbimazole.
• These validated methods are suitable for routine pharmaceutical analysis of carbimazole in tablets.