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Kinetic study of N-bromosuccinimide reactions and kinetic determination of pyridoxine using a bromide-selective
S A Halvatzis1, M M Timotheou-Potamia, C E Efstathiou
1Laboratory of Analytical Chemistry, University of Athens, Panepistimiopolis, 157 71, Athens, Greece.
Abstract:
The bromide released by the alkaline hydrolysis of N-bromosuccinimide and its reactions with bromide, pyridoxine and thiamine have been studied potentiometrically using a solid-state bromide-selective electrode to monitor the consumed or produced bromide ion. Potential-time indications are obtained using a microcomputer-controlled potentiometric system. The overall rate constants and the activation energies have been calculated. A kinetic-potentiometric procedure for the determination of pyridoxine in the presence of thiamine in pharmaceutical preparations, based on its reaction with N-bromosuccinimide, is presented.
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