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Related Experiment Video

Updated: Jun 28, 2026

Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

High performance optical absorbance detectors based on low noise switched integrators.

H Liu¹, P K Dasgupta, H J Zheng

¹Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, U.S.A.

|September 1, 1993

Summary

Researchers developed inexpensive optical absorption detectors with significantly lower noise levels (3 microAU) than current commercial options. This advancement enables highly sensitive liquid phase analysis, achieving a 10 nM limit of detection for bromothymol blue.

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Last Updated: Jun 28, 2026

Optical Trapping of Nanoparticles

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Published on: January 15, 2013

Wideband Optical Detector of Ultrasound for Medical Imaging Applications

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Published on: May 11, 2014

Implementation of a Reference Interferometer for Nanodetection

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Published on: April 26, 2014

Area of Science:

Analytical Chemistry
Instrumentation Science

Background:

Optical absorption detection is a primary technique for liquid phase analysis.
Current commercial detectors have peak-to-peak noise levels between 10-20 microabsorbance units (microAU).

Purpose of the Study:

To develop a cost-effective absorbance detector with improved noise performance.
To demonstrate the detector's capabilities using light-emitting diodes (LEDs) and capillary formats.

Main Methods:

Utilized switched integrator integrated circuit (IC) packages for detector circuitry.
Employed light-emitting diodes (LEDs) as light sources.
Tested performance in a capillary format with specific dimensions (50 x 1000 microm).

Main Results:

Achieved peak-to-peak noise levels as low as 3 microAU under operational conditions.
Observed 10 microAU noise levels in a capillary format with a <50 microm slitwidth.
Estimated a concentration limit of detection (LOD) of 10 nM for bromothymol blue (BTB) at 660 nm.

Conclusions:

Inexpensive absorbance detectors with significantly reduced noise are achievable using new IC technology.
The developed detector shows promise for sensitive analytical measurements, including in capillary applications.
This technology offers a cost-effective solution for enhancing liquid phase analysis sensitivity.