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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Flow-injection extraction-spectrophotometric determination of imipramine in pharmaceuticals with methyl orange
T Pérez-Ruiz1, C Martinez-Lozano, A Sanz
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain.
Talanta
|September 1, 1994
Abstract:
Imipramine in aqueous solution is extracted into 1,2-dichloroethane as its ion-pair with Methyl Orange in an unsegmented flow system and quantified spectrophotometrically. A linear calibration graph was obtained between 0.79 and 25.3 mug/ml of imipramine. Up to 45 samples/hr can be processed with a RSD of 0.88-1.6%. The method was satisfactorily applied to the determination of imipramine in pharmaceutical preparations.
