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Antigenic diversity of Cowdria ruminantium isolates determined by cross-immunity
F Jongejan1, M J Thielemans, C Brière
1Department of Tropical Veterinary Medicine and Protozoology, Institute of Infectious Diseases and Immunology, Utrecht, The Netherlands.
Research in Veterinary Science
|July 1, 1991
Abstract:
Antigenic diversity in five stocks of the tick-borne rickettsia Cowdria ruminantium, the causal agent of heartwater disease of ruminants, was studied by cross-immunity trials in goats and sheep. Complete absence of cross-protection was found only between the Kümm and Kwanyanga stocks, and in all other combinations there were various degrees of cross-immunity. Immunological strain differences were more pronounced in goats than in sheep.