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Latent infection of epidermal Langerhans cells in HIV-positive individuals
L R Braathen1, G Ramirez, R O Kunze
1Dept. Dermatol, Rikshospitalet, National Hospital, University of Oslo, Norway.
Research in Virology
|March 1, 1991
Abstract:
Epidermal cell suspensions obtained from 3 symptom-free HIV-positive individuals were cultured and marked with monoclonal antibodies for the HIV proteins p15, p24 and gp120 in the alkaline phosphatase anti-alkaline phosphatase staining technique. For 2 individuals, cells were positive after 3 days in culture, and for the third, after 4 days. Supernatant from one of the cultures infected allogeneic peripheral blood mononuclear cells. We conclude that epidermal Langerhans cells from symptom-free HIV-positive individuals are latent-infected and are able to produce and release HIV.