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TGF-beta: upregulator of HIV replication in macrophages
J K Lazdins1, T Klimkait, E Alteri
1Ciba-Geigy, Ltd., Pharma Research, Basel, Switzerland.
Research in Virology
|March 1, 1991
Abstract:
TGF-beta at physiological concentrations, when added to monocyte-derived macrophages following HIV1 infection, has an enhancing effect upon the rate of virus production. This effect is observed with the monocytotropic isolate ADA, as well as with HIV1 IIIB, which poorly replicates in macrophages.