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Sample Preparation for Analysis: Overview

Sample Preparation for Analysis: Overview

Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...

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Updated: Jun 28, 2026

Preparation of Food Samples Using Homogenization and Microwave-Assisted Wet Acid Digestion for Multi-Element Determination with ICP-MS

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Microwave-assisted sample preparation in analytical chemistry.

F E Smith, E A Arsenault

|August 1, 1996

Summary

Microwave-assisted sample preparation has revolutionized chemical analysis by significantly speeding up the slowest step. This review covers microwave dissolution and digestion methods developed up to 1994.

Area of Science:

Analytical Chemistry
Materials Science

Background:

Instrumentation for chemical analysis has advanced rapidly.
Sample preparation methods lagged behind, becoming a bottleneck.
Microwave ovens have become increasingly common in laboratories.

Purpose of the Study:

To review microwave-assisted dissolution and digestion methods.
To summarize developments up to 1994.
To discuss recent advancements in automated systems and databases.

Main Methods:

Review of literature on microwave-assisted dissolution and digestion.
Analysis of applications since 1975.
Inclusion of continuous-flow automated dissolution systems.
Discussion of databases and software for microwave technology.

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Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

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Main Results:

Microwave technology has dramatically improved chemical sample preparation speed and efficiency.
Numerous microwave-assisted dissolution methods are applicable to diverse sample types.
Recent developments include automated systems and specialized software.

Conclusions:

Microwave technology is revolutionizing chemical sample preparation and synthesis.
The review provides a comprehensive summary of methods up to 1994.
Emerging technologies enhance the application of microwave technology in dissolution.