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Updated: Jun 28, 2026

O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression
Published on: November 8, 2019
Simultaneous spectrophotometric determination of drugs in pharmaceutical preparations using multiple linear
Abstract:
Two new methods for the simultaneous determination of acetylsalicylic acid, acetaminophen and caffeine based on total absorbance measurements and their processing by multiple linear regession and partial least-squares regression are proposed. The concentration ranges used to construct the calibration matrix were 4.0-12.0, 2.0-10.0 and 0.9-6.0 mug ml(-1) for acetylsalicylic acid, acetaminophen and caffeine respectively. The proposed methods were validated by using a set of synthetic sample mixtures and subsequently applied to the determination of the three active principles in three different pharmaceutical preparations.
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