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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Fluorimetric properties of a 2-hydroxypropyl-beta-cyclodextrin: 9-methyl-benzo[a]phenothiazine inclusion complex in
M Maafi1, M C Mahedero, J J Aaron
1Institut de Topologie et de Dynamique des Systèmes de l'Université de Paris 7, Denis Diderot, associé au CNRS, URA-34, 1, rue Guy de la Brosse, 75005 Paris, France.
Abstract:
The formation of an inclusion complex between 9-methyl-12H-benzo[a]phenothiazine (MeBPHT) and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was investigated in aqueous medium. A 12-fold fluorescence emission intensity enhancement was found for the complexed relative to the free analyte. MeBPHT forms a 1:1 stoichiometry complex with HP-beta-CD. A formation constant of 460 (+/-100) M(-1) was calculated using the Benesi-Hildebrand method and fluorimetric data. The limit of detection was 7 ng ml(-1) for MeBPHT in the presence of HP-beta-CD instead of 60 ng ml(-1) in the absence of HP-beta-CD.
