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Published on: April 23, 2019
Permanganate-based chemiluminescence analysis of cefadroxil monohydrate in pharmaceutical samples and biological
F A Aly1, N A Alarfaffj, A A Alwarthan
1Department of Chemistry, College of Science, Women Student-Medical Studies, Sciences Section, King Saud University, PO Box 22452, Riyadh 11495, Saudi Arabia.
Abstract:
A chemiluminescent method using flow injection is described for the determination of cefadroxil monohydrate. The method is based on the chemiluminescence reaction of cefadroxil with potassium permanganate in sulphuric acid, sensitized by quinine. The proposed procedure allows the determination of cefadroxil over the concentration range 0.1-30 mug ml(-1) with a detection limit of 0.05 mug ml(-1) and a sample measurement frequency of 150 samples h(-1). The method was successfully applied to the determination of cefadroxil in pharmaceutical preparations and biological fluids.
