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[The biochemistry of psoriasis]
Annales De Dermatologie Et De Syphiligraphie
|January 1, 1976
Summary
Psoriasis disrupts general metabolism, increasing risks for diabetes and lipid issues. Skin cells exhibit altered glucose metabolism, increased DNA synthesis, and abnormal lipid processing.
Area of Science:
- Biochemistry
- Dermatology
- Metabolic Disorders
Context:
- Psoriasis is a chronic inflammatory skin condition associated with systemic metabolic disturbances.
- Previous research indicates links between psoriasis and conditions like diabetes mellitus, hyperuricemia, and lipid abnormalities.
Purpose:
- To investigate the specific alterations in cutaneous and general metabolism associated with psoriasis.
- To identify key metabolic pathways and molecules affected in psoriatic lesions and surrounding skin.
Summary:
- Psoriasis is linked to widespread metabolic dysregulation, including increased incidence of diabetes mellitus, hyperuricemia, and lipid disturbances.
- Cutaneous metabolism is significantly altered, with excessive glucose metabolism leading to increased production of amino acids, fatty acids, sterols, lactic acid, ribose, ribulose, and uronic acids.
- Abnormalities include glycogen accumulation, increased lipogenesis and lipolysis, decreased cholesterol esterification, diminished ATP utilization, increased collagen renewal, and elevated DNA synthesis in psoriatic lesions.
Impact:
- Understanding these metabolic changes can provide insights into the pathogenesis of psoriasis and its comorbidities.
- Identifies potential therapeutic targets for managing psoriasis and its associated metabolic complications.
- Highlights the systemic nature of psoriasis, extending beyond the skin to affect overall metabolic health.