Related Experiment Video
Updated: Jun 28, 2026

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
Published on: May 4, 2020
Modelling the matrix interference of iron in the multivariate determination of copper by stripping voltammetry
1Dpto. Quimica, Facultad de Ciencias, Universidad de Burgos, Pza. Misuel Banuelos s/n, Burgos, Spain. aherrero@ubu.es
Abstract:
Two different standardization procedures have been applied in order to minimize the experimental effort necessary to determine copper in presence of iron by differential pulse anodic stripping voltammetry. The significant matrix interference caused by iron in the voltammetric determination of copper has been successfully solved by using partial least squares (PLS) regression. The use of this multivariate regression implies a large number of training set samples, so a standardization method was required. In fact, the standardization methods used have reduced the calibration samples needed in future determinations by up to 75%. Moreover, PLS regression allowed both metals to be determined simultaneously by using an adequate experimental design, without any limitation to their respective concentrations and without the need to know the level of interference.
Related Concept Videos
Voltammetry: Stripping Methods
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
Voltammetry: Factors Affecting Measurements
Electrodeposition
Electrodeposition can...
Atomic Absorption Spectroscopy: Interference
Spectral interference occurs when signals from other elements or molecules overlap with the analyte signal, falsely elevating or masking the analyte's absorbance. This interference can be corrected using Zeeman,...
Voltammetric Techniques: Cyclic Voltammetry

