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Published on: April 23, 2019
Simultaneous detection of S and R captopril using sequential injection analysis
R I Stefan1, J K van Staden, H Y Aboul-Enein
1Department of Chemistry, University of Pretoria, Pretoria, 0002, South Africa.
Abstract:
A simultaneous detection sequential injection analysis (SIA) system is proposed for the determination of S and R captopril using a potentiometric, enantioselective membrane electrode based on maltodextrin (DE=14-17) for the assay of S-captopril and an amperometric biosensor for the assay of R-captopril. The proposed SIA system can be utilized reliably for the on-line simultaneous detection of the enantiomers in the synthesis process at a rate of 38 samples per hour in the following linear concentration ranges: 100-1000 nmol/l (R-captopril) and 1-1000 mumol/l (S-captopril) with a RSD better than 0.009% (n=10).
