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Electrocatalytic oxidation of L-tyrosine by a nitroxide
1Department of Physics, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Abstract:
The electrochemistry of L-tyrosine was studied by cyclic voltammetry at a glassy carbon electrode. Although L-tyrosine itself showed very poor electrochemical response, the response could be greatly enhanced by using 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy (HO-TEMPO) as a mediator that enables a sensitive determination of the substrate. An electrocatalytic EC' mechanism with the oxoammonium ion of HO-TEMPO as the active oxidant is proposed. The catalytic rate constant was determined to be 2.0 x 10(4) M(-1) s(-1) by using chronoamperometry.
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