Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Micelles of a diblock copolymer of styrene and ethylene oxide in mixtures of 2,6-lutidine and water.

Langmuir : the ACS journal of surfaces and colloids·2009
Same author

[Selective depletion of alloreactive T cells and study of anti-tumor activity of specific T cell clones in patients with leukemia].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2008
Same author

Comparison of zirconia- and silica-based reversed stationary phases for separation of enkephalins.

Journal of chromatography. A·2005
Same author

Chiral separation of beta-adrenergic antagonists, profen non-steroidal anti-inflammatory drugs and chlorophenoxypropionic acid herbicides using teicoplanin as the chiral selector in capillary liquid chromatography.

Journal of chromatography. A·2005
Same author

Comparison of vancomycin-based stationary phases with different chiral selector coverage for enantioselective separation of selected drugs in high-performance liquid chromatography.

Journal of chromatography. A·2005
Same author

[Lymphocyte immunophenotyping and cytogenetics for more precise prognosis in patients with type B chronic lymphatic leukemia].

Casopis lekaru ceskych·2003

Related Experiment Video

Updated: Jun 28, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining
08:04

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

Study on the aggregation of teicoplanin.

E Tesarová1, Z Tuzar, K Nesmerák

  • 1Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Albertov 2030, 12840, Prague 2, Czech Republic.

Talanta
|October 31, 2008
PubMed
Summary

Teicoplanin aggregation and micelle formation were investigated. Acetonitrile addition prevented micelle formation, indicating different solvation and association mechanisms.

More Related Videos

Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor
07:59

Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor

Published on: June 29, 2021

Related Experiment Videos

Last Updated: Jun 28, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining
08:04

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor
07:59

Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor

Published on: June 29, 2021

Area of Science:

  • Pharmaceutical Sciences
  • Physical Chemistry

Background:

  • Teicoplanin is a complex glycopeptide antibiotic.
  • Understanding teicoplanin's aggregation behavior is crucial for its formulation and efficacy.
  • Solvent effects on drug aggregation are significant.

Purpose of the Study:

  • To investigate the aggregation of teicoplanin in different buffer solutions.
  • To determine the critical micelle concentration (CMC) of teicoplanin.
  • To elucidate the influence of acetonitrile on teicoplanin's self-assembly.

Main Methods:

  • Conductometry
  • Capillary electrophoresis
  • Cyclic voltammetry
  • Static light scattering
  • Dynamic light scattering

Main Results:

  • Teicoplanin exhibited critical micelle concentration (CMC) in phosphate buffers.
  • No CMC was detected in solutions containing 10% acetonitrile.
  • Particle size and distribution were analyzed using dynamic light scattering.

Conclusions:

  • Acetonitrile significantly alters teicoplanin's aggregation behavior.
  • Different solvation mechanisms are proposed for solutions with and without acetonitrile.
  • Two distinct association schemes were identified based on solvent composition.