A sulpha-drug sensitive sensor based on ion-pair complex modified PQC resonator

Area of Science:

• Analytical Chemistry
• Materials Science

Background:

• Sulpha-drugs are widely used antibiotics, necessitating reliable detection methods.
• Existing detection techniques may lack sensitivity or selectivity.
• Development of novel sensing materials is crucial for pharmaceutical analysis.

Purpose of the Study:

• To develop and characterize a novel piezoelectric sensor for the detection of sulpha-drugs.
• To investigate the performance and influencing factors of the proposed sensor.

Main Methods:

• Construction of a piezoelectric sensor incorporating an ion-pair complex of sulphadiazine-cetyltrioctylammonium and cholestyramine in a PVC matrix.
• Evaluation of sensor response, selectivity, and detection limit under optimized conditions.
• Investigation and optimization of factors affecting sensor performance, such as pH.

Main Results:

• The developed sensor demonstrated a sensitive mass response to sulpha-drugs.
• The sensor exhibited reasonable selectivity for sulpha-drugs.
• The response range was found to be between 1.0x10(-7) and 1.0x10(-5) M, with a detection limit of 8x10(-8) M at pH 8.63.

Conclusions:

• The novel piezoelectric sensor offers a promising approach for sensitive and selective sulpha-drug detection.
• The sensor's performance can be optimized by controlling various influencing factors.
• This sensor has potential applications in pharmaceutical analysis and quality control.