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Determination of paracetamol in pharmaceutical formulations using a sequential injection system
J Koos F van Staden1, M Mutshutshu Tsanwani
1Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa.
Talanta
|October 31, 2008
Summary
A new, rapid method accurately determines paracetamol in pharmaceuticals. This technique uses potassium hexacyanoferrate(III) oxidation and reaction with phenol for precise quantification.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Accurate quantification of paracetamol is crucial for pharmaceutical quality control.
- Existing methods may lack speed or simplicity for routine analysis.
Purpose of the Study:
- To develop a simple and rapid analytical method for paracetamol determination.
- To validate the method for use in pharmaceutical formulations.
Main Methods:
- Oxidation of paracetamol using potassium hexacyanoferrate(III).
- Reaction of oxidized paracetamol with phenol in an ammonia medium.
- Spectrophotometric measurement of the resulting blue complex at 630 nm.
Main Results:
- The method achieved a sample throughput of 27 samples per hour.
- A low detection limit of 0.2 mg L⁻¹ was established.
- Linearity was observed up to 60 mg L⁻¹, with a relative standard deviation of 1.2% (n=10).
Conclusions:
- The described method offers a fast, simple, and accurate approach for paracetamol quantification.
- This technique is suitable for the routine analysis of paracetamol in pharmaceutical products.
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