[Hemostatic and adhesive properties of fibrin tissue glue in an experiment]

The authors compared in experiments the adhesive properties and haemostatic action of the foreign preparation Tissucol with a gluing system elaborated from locally produced constituents. The lack of availability of foreign fibrin tissue glues leads to their inadequate use in our departments. Readily available local preparations can reduce this shortcoming. They are, however, not adequately used so far. The objective of the present work was to test the adhesive and haemostatic action of several gluing systems, which differ by their fibrinogen concentration. The gluing systems were created by a similar composition and concentration as Tissucol. Experiments were performed on 22 rabbits under general i.v. and i.m. anaesthesia. The adhesive properties were tested by the firmness of a glued skin autotransplant, the haemostatic action by gluing a bleeding piercing wound of the liver. The authors proved the effectiveness of all used fibrin systems which have different qualities. The properties of Tissucol were matched only by a glue with a high fibrinogen and thrombin concentration. Our presentations can reliably replace foreign fibrin glues.