Bia-amperometric quantification of salbutamol in pharmaceutical products

This paper presents a simple, rapid and reproducible method of analysis of salbutamol in pharmaceutical products, utilizing batch injection analysis (BIA) associated with amperometric detection. A study of salbutamol oxidation demonstrated a strong dependence between electrode fouling and pH. All determinations were done utilizing a glassy carbon electrode in presence of 3.0moll(-1) NaOH. A large linear dynamic range from 8x10(-7) to 2x10(-4)moll(-1) was obtained by using an injected volume of 100mul with a detection limit of 2.5x10(-7)moll(-1). R.S.D. of 0.92% for 50 successive injections of 4x10(-6)moll(-1) of salbutamol and a sample throughput of 60 samples per hour were achieved. The method was applied for salbutamol quantification in syrups.