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Updated: Jun 28, 2026

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
Published on: March 2, 2012
Organic tin compounds combined with anionic additives-an ionophore system leading to a phosphate ion-selective
S Sasaki1, S Ozawa, D Citterio
1Department of Applied Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Abstract:
The potentiometric response characteristics of electrodes based on organic trialkyl/aryl-tin compounds combined with various amounts of anionic additive (NaTFPB) were investigated in 0.1M bis-Tris-H(2)SO(4) buffer solution at pH 7.0. The best result for phosphate sensing was obtained for the electrode membrane containing tributyltin chloride and 25mol% NaTFPB, where the electrode exhibits high selectivity towards phosphate anions with a slope of -60mV per decade. It was demonstrated that the interference from more lipophilic anions is drastically suppressed (log K (ij)(pot ), i=H(2)PO(4)(-): salicylate, 0.5; SCN(-), -0.8; ClO(4)(-), -2.3) under this optimized measurement conditions.
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