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Related Experiment Video

Updated: Jun 28, 2026

Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research

Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research

Published on: April 18, 2013

A portable automated multianalyte biosensor.

Joel P Golden¹, Chris R Taitt, Lisa C Shriver-Lake

¹Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Code 6900, Washington, DC 20375-5348, USA.

|October 31, 2008

Summary

This summary is machine-generated.

This study miniaturized and automated an array biosensor for portable, on-site detection of multiple targets. The redesigned fluidics enable reliable, simultaneous quantification of analytes in complex samples.

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Area of Science:

Analytical Chemistry
Biotechnology
Sensor Technology

Background:

Array biosensors utilize capture molecules on optical waveguides for simultaneous multi-target detection.
Previous work established the biosensor's capability for rapid target identification in complex matrices.

Purpose of the Study:

To miniaturize and automate the array biosensor for enhanced portability and on-site application.
To redesign fluidics for reliability and commercial production of disposable components.

Main Methods:

Redesign and construction of miniaturized fluidics for automated sample handling.
Simultaneous, automated assays for target analytes (ovalbumin, staphylococcal enterotoxin B).
Utilized planar optical waveguide technology for interrogating multiple samples.

Main Results:

Demonstrated successful miniaturization and automation of the array biosensor system.
Achieved reliable, simultaneous detection and quantification of multiple targets.
Validated performance in complex sample matrices.

Conclusions:

The automated, miniaturized array biosensor is suitable for portable, on-site detection.
Redesigned fluidics support reliable operation and commercial viability.
The system effectively quantifies analytes in real-world sample conditions.