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[Plasma fibrinogen and cardiovascular disease]
L F Møller1, J Jespersen, T S Kristensen
1Københavns Universitet, Panum Instituttet, Institut for Social Medicin.
Insights
Plasma fibrinogen levels are linked to cardiovascular disease risk, even after accounting for traditional factors. Lifestyle and psychosocial variables also significantly correlate with higher fibrinogen levels.
Area of Science:
- Epidemiology
- Biochemistry
Context:
- Prospective epidemiological studies investigate plasma fibrinogen.
- Cardiovascular disease (CVD) risk factors are well-established.
Purpose:
- To explore the correlation between plasma fibrinogen levels and cardiovascular diseases.
- To investigate the association of lifestyle and psychosocial factors with fibrinogen levels.
Summary:
- Plasma fibrinogen levels show a correlation with cardiovascular diseases, independent of major risk factors.
- Lifestyle variables like smoking, inactivity, and diet positively correlate with fibrinogen.
- Psychosocial variables are also closely correlated with fibrinogen levels, even after adjusting for established risk factors.
Impact:
- Highlights fibrinogen as a potential biomarker for cardiovascular risk.
- Suggests lifestyle and psychosocial interventions may influence fibrinogen levels.
- Informs public health strategies for cardiovascular disease prevention.
Abstract:
In prospective epidemiological studies the plasma fibrinogen level is correlated to cardiovascular diseases even after statistical correction for the major risk factors. The fibrinogen level is positively correlated with many risk factors such as life-style variables including smoking, lack of physical activity and high-fat diet. Psychosocial variables are in many studies closely correlated with the fibrinogen level even after adjustment for the traditional (established) risk factors.